A 19,109 patient, British observational study described the effectiveness of COVID-19 vaccines against the Delta variant. The effectives of the Pfizer-BioNTech COVID-19 vaccine was estimated to be 88% after two doses and 67% with two doses of the AstraZeneca vaccine.
An analysis of data by Israeli researchers found the effectiveness of the Pfizer-BioNTech COVID-19 vaccine to be 91% to prevent severe disease and 88% to prevent hospitalizations. The vaccine had an estimated effectiveness of 41% to protect against symptomatic disease and 39% to prevent infection due to the Delta variant compared to an estimated 64% effectiveness at the beginning of July.
Mesoblast announced that in a 60-day, 222 patient, Phase III trial (NCT04371393), treatment with remestemcel-L added to standard of care (SOC) did not reduce all-cause mortality compared to SOC in ventilator-dependent patients with moderate to severe acute respiratory distress syndrome (ARDS) due to COVID-19. In a pre-specified analysis of 123 patients under age 65, remestemcel-L reduced mortality by 46% by day 60, but not in 94 patients 65 or older. The Data Safety Monitoring Board (DSMB) recommended the trial be stopped when an interim analysis of 30-day data for 180 patients found it unlikely the trial would achieve a 43% reduction in mortality at the target enrollment of 300 patients. The DSMB recommended the trial be completed with the 222 patients already enrolled.
Stay informed, subscribe to the Prescribe Right Pharmaceutical Pipeline Tracker