AT-527 is an antiviral being developed by Atea Pharmaceuticals to treat Hepatitis C. AT-527 is a purine nucleotide prodrug that inhibits viral replication by interfering with viral RNA polymerase. The drug has demonstrated in vitro and in vivo antiviral activity against enveloped single-stranded RNA viruses, such as human flaviviruses and coronaviruses. Due to activity on coronaviruses, Atea began developing the drug as a treatment for COVID-19. Roche licensed development and marketing rights for AT-527 outside the U.S.
In the 28-day, 464 patient, open-label, PLACID trial, treatment with convalescent plasma did not reduce progression to severe disease or all-cause mortality (19% vs 18%), despite an almost 20% greater conversion to a negative SARS-CoV-2 test on day seven in hospitalized Indian patients with moderate COVID-19. Patients in the trial were treated with antivirals (hydroxychloroquine, remdesivir, lopinavir/ritonavir, oseltamivir), broad spectrum antibiotics and immunomodulators (steroids, tocilizumab).
The FDA allowed the Phase III trial for AstraZeneca’s coronavirus vaccine, AZD1222, to resume in the US, on 10/23/2020 after an FDA review of all safety data concluded the vaccine was safe.
Johnson & Johnson will resume the Phase III ESEMBLE trial in October 2020, after a Data Safety and Monitoring Board review found no evidence that COVID-19 vaccine candidate, Ad26.COV2-S, caused a serious medical event experienced by one study participant.
COVID-19 Monoclonal Antibodies
Lilly announced that NIAID discontinued the Phase III, ACTIV-3 trial (NCT04501978), when an interim analysis did not find an improvement when bamlanivimab was added to remdesivir compared to remdesivir alone in hospitalized patients with COVID-19.